Stereotypic Immune System Development in Newborn Children
By Axel Olin, E. Henckel, Yang Chen, T. Lakshmikanth, Christian Pou, J. Mikeš, A. Gustafsson, A. Bernhardsson, Cheng Zhang, K. Bohlin and 1 more. Cell, 2018
614 citations recorded by the source corpus.
Summary Epidemiological data suggest that early life exposures are key determinants of immune-mediated disease later in life. Young children are also particularly susceptible to infections, warranting more analyses of immune system development early in life. Such analyses mostly have been performed in mouse models or human cord blood samples, but these cannot account for the complex environmental exposures influencing human newborns after birth. Here, we performed longitudinal analyses in 100 newborn children, sampled up to 4 times during their first 3 months of life. From 100 μL of blood, we analyze the development of 58 immune cell populations by mass cytometry and 267 plasma proteins by immunoassays, uncovering drastic changes not predictable from cord blood measurements but following a stereotypic pattern. Preterm and term children differ at birth but converge onto a shared trajectory, seemingly driven by microbial interactions and hampered by early gut bacterial dysbiosis.
Subfields: Molecular Biology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/79cfcda03e30e5080fd8d84fc72c6c305e4aa26c
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In Molecular Biology
Citations in the corpus
- Spatiotemporal analysis of human intestinal development at single-cell resolution (2021, neutral): “The intestine is a site of immune cell priming at birth (Olin et al., 2018), and defects in the ontogeny of intestinal immune cells are”
- The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19 (2020, neutral): “Our results showing lower naive CD4 T cell, TFH, and increases in central and effector memory subpopulations in MISC as compared to Kawasaki disease patients could be partially explained by differences in patient age, because immune cell proportions change with age, even in healthy children (Olin et”
- Bifidobacteria-mediated immune system imprinting early in life (2020, background): “We previously unraveled a postnatal adaptation by the newborn immune system to environmental exposures (Olin et al., 2018).”