Phospholipase Cβ serves as a coincidence detector through its Ca[2+] dependency for triggering retrograde endocannabinoid signal

By 祐輝橋本谷. 2005

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Spike timing-dependent plasticity: a Hebbian learning rule. (2008, unknown): “Signaling through mGluRs can lead to phospholipase C (PLC) activation, and Ca2+ influx through VDCCs can facilitate mGluR-dependent-PLC activation (Hashimotodani et al. 2005, Maejima et al. 2005).”
The spike timing dependence of plasticity (2012, background): “Strong evidence suggests that the order-dependent coincidence detector is the IP3 receptor, which is coactivated by PLC-produced IP3 and VSCC-derived cytosolic calcium (Nakamura et al., 1999; Wang et al., 2000; Sarkisov and Wang, 2008).”
Distinct coincidence detectors govern the corticostriatal spike timing‐dependent plasticity (2010, unknown): “PLCβ acts as coincidence detector for t-LTD At hippocampal synapses, PLCβ acts as an efficient coincidence detector triggering retrograde endocannabinoid signalling to mediate short-term plasticity (Hashimotodani et al. 2005, 2008).”
Striatal plasticity and basal ganglia circuit function (2008, unknown): “…MSN depolarization using cesium-filled electrodes is required to trigger LTD. Activation of mGluRs and L-type channels leads to endocannabinoid production and release, possibly through phospholipase Cb, which is both Gq receptor dependent and calcium sensitive (Hashimotodani et al., 2005).”