NKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway

By M. Terabe, S. Matsui, N. Noben-Trauth, Hangjiong Chen, C. Watson, D. Donaldson, D. Carbone, W. E. Paul, J. Berzofsky. Nature Immunology, 2000

752 citations recorded by the source corpus.

Subfields: Immunology

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Going both ways: immune regulation via CD1d-dependent NKT cells. (2004, background): “The suppressive effect in the 15-12RM model was IL-13 dependent/IL-4 independent (97) and appeared to involve TGF-β production by a Gr-1+ myeloid cell that led to impaired CTL responsiveness (99).”
Distinct Functional Lineages of Human Vα24 Natural Killer T Cells (2002, background): “In another report, secretion of the Th2 cytokine IL-13 was found to inhibit the immune rejection of a tumor graft (10).”
Immunosuppressive strategies that are mediated by tumor cells. (2007, background): “These cells showed impaired effector functions when TGF-β was present in T-cell cultures.”
Myeloid derived suppressor cells promote cross-tolerance in B cell lymphoma by expanding regulatory T cells (2008, background): “Because most MDSC suppressive pathways can be inhibited by down-regulating IL4Ra (17, 22, 28, 29), we asked if sildenafil could also reverse tumor-induced T-cell anergy and Treg proliferation.”