Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers

By F. Gu, Liangfang Zhang, Benjamin A. Teply, Nina Mann, Andrew Wang, A. Radovic-Moreno, Robert Langer, O. Farokhzad. Proceedings of the National Academy of Sciences of the United States of America, 2008

715 citations recorded by the source corpus.

Subfields: Biomaterials, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/87aab6181d237dda6a7f1db2fb3c612b98375bde

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Citations in the corpus

The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles (2011, neutral): “The development of NPs by the self-assembling of pre-functionalized subunits would eliminate the need of post-particle modification, and may have less batch-to-batch variation [23].”
PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery. (2009, background): “Herein we report the parameters that alter the biological and physicochemical characteristics, stability, drug release properties and cytotoxicity of these core–shell NPs.”
PEGylation as a strategy for improving nanoparticle-based drug and gene delivery (2015, neutral): “In a targeted cancer therapy study, the optimal drug release profile, range for surface aptamer content, and maximal stealth properties were precisely controlled through the blending of PLGA-PEG and PLGA-PEG-aptamer using the nanoprecitation method [198].”
Designing materials to direct stem-cell fate (2009, background): “Specifically, they can be functionalized so that they bind to specific molecules on cells, are responsive to environmental signals such as proteases secreted by cells, or are delivered encapsulated in a manner that leads to temporally controlled release or cellular uptak”
Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform. (2008, background): “A recent report from our laboratory demonstrated the advantages of forming targeted NPs in a single-step process using a mixture of PLGA PEG diblock copolymers and preformed PLGA PEG aptamer triblock copolymers.(18) In contrast to the conventional two-step process that PLGA PEG NPs were first prepar”
Impact of nanotechnology on drug delivery. (2009, background): “relative to nontargeted drug delivery systems,(29) the difference in cellular cytotoxicity is more pronounced.(20,30,34) In the case of vascular endothelial targeting for oncology or cardiovascular indications, ligand-mediated targeting is of critical importance as tissue accumulation is not a funct”