Uncovering molecular mechanisms involved in activation of G protein-coupled receptors.

By U. Gether. Endocrine reviews, 2000

1,214 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/87794cf46343bb63cf88c73a1c33c18ebd8abd2f

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In Cellular and Molecular Neuroscience

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In Nutrition and Dietetics

Citations in the corpus

Mammalian G proteins and their cell type specific functions. (2005, background): “However, despite the determination of the structure of rhodopsin at atomic resolution (504), it is still not clear how specificity of the receptor-G protein interaction is achieved and how a ligand-induced conformational change in the receptor molecule results in G protein activation (177, 212, 213,”
Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands (2002, background): “They respond to a wide range of stimuli including small peptides, lipid analogs, amino-acid derivatives, and sensory stimuli such as light, taste and odor [1], and transmit signals to the interior of the cell through interaction with heterotrimeric G proteins.”
Ser and Thr Residues Modulate the Conformation of Pro-Kinked Transmembrane α-Helices (2004, background): “for membrane proteins (Gether, 2000).”
Evolutionarily conserved networks of residues mediate allosteric communication in proteins (2003, neutral): “For example, ligand binding at an externally accessible site in G protein–coupled receptors (GPCRs) reliably triggers structural changes at distant cytoplasmic domains that mediate interaction with heterotrimeric G protein”
G-Protein-coupled receptor oligomerization and its potential for drug discovery (2002, background): “GPCRs can be grouped on the basis of sequence homology into several distinct familie”
Identification and characterization of a novel family of Drosophilaβ‐adrenergic‐like octopamine G‐protein coupled receptors (2005, background): “39 which has again been suggested to have ionic interactions with the amine group of the biogenic amines in adrenoceptors (Gether 2000) and which has been substituted with a phenylalanine and the absence of N6.”
The lutropin/choriogonadotropin receptor, a 2002 perspective. (2002, background): “These two papers conclusively established that the LHR is a single polypeptide chain with an overall structure and topology that made it a member of the rhodopsin/ 2-adrenergic receptor subfamily (4, 5) of G protein-coupled receptors (GPCRs).”
Subcellular targeting strategies for drug design and delivery (2010, background): “Ligand-induced conformational changes of transmembrane domain 3 (TM3) and TM6 of GPCRs initiate downstream signalling, and the third intracellular loop (i3 loop) is essential for the coupling between the receptor and the G protei”
Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors (2002, background): “Leff (1995), Gether and Kobilka (1998), Gether (2000), Daeffler and Landry (2000) and Kenakin (2001) covered the theoretical basis of constitutive GPCR activation and the mechanisms of GPCR activation in general.”
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. (2010, neutral): “…to GPCRs to stimulate and induce a variety of cellular responses via several second messenger pathways; e.g., modulation of cAMP production, the phospholipase C pathway, ion channels, and mitogen-activated protein kinases (Ulloa-Aguirre et al., 1999; Gether, 2000; Schulte and Fredholm, 2003.”
Protein-ligand interaction prediction: an improved chemogenomics approach (2008, background): “In the case of enzymes, it can be explained by the diversity of the proteins in the family and for the GPCR, by the well-known fact that the receptors do not share overall sequence homology (Gether, 2000).”