Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

By K. Karrouchi, S. Radi, Y. Ramli, J. Taoufik, Y. Mabkhot, Faiz A. Al-aizari, M. Ansar. Molecules, 2018

791 citations recorded by the source corpus.

Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antipsychotic CDPPB, the anti-obesity drug rimonabant, difenamizole, an analgesic, betazole, a H2-receptor agonist and the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Owing to this diversity in the biological field, this nucleus has attracted the attention of many researchers to study its skeleton chemically and biologically. This review highlights the different synthesis methods and the pharmacological properties of pyrazole derivatives. Studies on the synthesis and biological activity of pyrazole derivatives developed by many scientists around the globe are reported.

Subfields: Computational Theory and Mathematics, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/872f7cd1e769826d90a7be8263e3ca5409120199

Citations in the corpus

• A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications (2020, neutral): “  S. No  Structure  Drug Name  Activity  1    Ezetimibe  Cholesterol absorption inhibitor  [27]  2    Clavulanic acid  β‐Lactamase inhibitor [28]  3    Carboxyamidotriazole  Calcium channel blocker as an  anti‐cancer [29]  4    Oxiconazole  Antifungal [30]  5    Dacarbazine  Treatment of metastatic ”