A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications

By Nagaraju Kerru, Lalitha Gummidi, S. Maddila, Kranthi Kumar Gangu, Sreekanth B. Jonnalagadda. Molecules, 2020

1,175 citations recorded by the source corpus.

The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties. In the forthcoming decade, a much greater share of new nitrogen-based pharmaceuticals is anticipated. Many new nitrogen-based heterocycles have been designed. The number of novel N-heterocyclic moieties with significant physiological properties and promising applications in medicinal chemistry is ever-growing. In this review, we consolidate the recent advances on novel nitrogen-containing heterocycles and their distinct biological activities, reported over the past one year (2019 to early 2020). This review highlights the trends in the use of nitrogen-based moieties in drug design and the development of different potent and competent candidates against various diseases.

Subfields: Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/43d114f6e23bb86b1d0236e74c2c323f0c8220a1