Role of CD47 as a marker of self on red blood cells.

By P. Oldenborg, A. Zheleznyak, Yi Fang, C. Lagenaur, H. Gresham, F. Lindberg. Science, 2000

1,893 citations recorded by the source corpus.

Subfields: Hematology, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/87057d9f19abf00aaa26480d3a56b46a9b2146e7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. Irving L. Weissman
2. R. Majeti
3. Siddhartha Jaiswal
4. Catriona H. M. Jamieson
5. M. Clarke
6. Christopher Y. Park
7. W. Pang
8. S. Mitragotri

In Immunology

1. Irving L. Weissman
2. R. Majeti
3. W. Pang
4. Katsumori Segawa
5. M. Chao
6. Hans Lassmann
7. S. Nagata
8. Aldons J. Lusis

In Physiology

1. Katsumori Segawa
2. S. Nagata
3. Siddhartha Jaiswal
4. S. Mitragotri
5. R. DePinho

Citations in the corpus

• An Apoptotic 'Eat Me' Signal: Phosphatidylserine Exposure. (2015, background): “Among these molecules, CD47 is thought to be a strong candidate because CD47deficient red blood cells injected into mice are rapidly cleared from the bloodstream by splenic macrophages [87].”
• MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. (2009, background): “CD47 inhibits the phagocytic activity of macrophages (Oldenborg et al., 2000; Yamao et al., 2002; Ishikawa-Sekigami et al., 2006) and cytokine production of dendritic cells via signal regulatory protein-a (Latour et al., 2001).”
• CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells (2009, neutral): “Oldenborg et al., 2000, 2001).”
• CD47 blocking antibodies restore phagocytosis and prevent atherosclerosis (2016, methodology): “Here we show that atherogenesis is associated with upregulation of CD47, a key anti-phagocytic molecule that is known to render malignant cells resistant to programmed cell removal, or ‘efferocytosis’ 4–7 .”
• The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors (2012, background): “CD47 functions as a ligand for signal regulatory protein-α (SIRPα), a protein expressed on macrophages and dendritic cells (7).”
• Bio-inspired, bioengineered and biomimetic drug delivery carriers (2011, background): “A membrane protein, CD47, that is present on all cells was shown to signal inhibition of the phagocytic activity of macrophage”
• CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. (2009, positive): “Lack of autonomous CD47 expression results in phagocytosis of red blood cells (Oldenborg et al., 2000), as well as T cells and whole bone marrow cells in a transplant setting (Blazar et al., 2001).”