Herpesvirus latency confers symbiotic protection from bacterial infection

By E. Barton, D. White, Jason S. Cathelyn, Kelly A. Brett-McClellan, Michael J. Engle, Michael S. Diamond, V. Miller, Herbert W. Virgin. Nature, 2007

745 citations recorded by the source corpus.

Subfields: Epidemiology, Parasitology

View Paper: https://www.semanticscholar.org/paper/86fa152bcef70ec9eafb381aae2cf8efea58a628

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Citations in the corpus

The Impact of the Gut Microbiota on Human Health: An Integrative View (2012, neutral): “For example, although herpesvirus can cause acute disease, latent herpesvirus infection has been shown to protect mice against the bacterial pathogens Listeria monocytogenes and Yersinia pestis by stimulating increased levels of interferon-g and tumor necrosis factor (Barton et al., 2007).”
The Bacterial Symbiont Wolbachia Induces Resistance to RNA Viral Infections in Drosophila melanogaster (2008, background): “This would be similar to what happens in a herpesvirus-induced resistance to Listeria in mice, due to the production of cytokines [59].”
Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity (2012, background): “Despite this apparent specialization, crosstalk between pathways has been reported in which stimulation from one class of pathogens influences the response to another (Barton et al., 2007; Spencer et al., 1977).”
Microbiome and Malignancy (2011, background): “Such interactions favor EBV persistence, yet EBV latency may also provide mutualistic benefit to its hosts as an immune adjuvant (White et al., 2010), protecting against lethal Listeria monocytogenes and Yersinia pestis infections (Barton et al., 2007).”
An emerging paradigm of colony health: microbial balance of the honey bee and hive (Apis mellifera) (2011, background): “Healthy humans harbor an abundance of latent (inactive) viruses, some of which represent symbiotic relationships that confer host resistance to major bacterial pathogens (Barton et al., 2007).”
Antibiotic-Producing Bacteria as a Possible Defence of Birds against Pathogenic Microorganisms (2010, background): “Symbiont-mediated-protection has mainly been studied in invertebrate hosts [1, 11, 13, 14], but recent studies also provide evidence for its existence in vertebrates, including amphibians [15], birds [16], and mammals [17].”
Trained immunity: a memory for innate host defense. (2011, background): “In contrast to this classical cross-protection, memory lymphocytes also mediate long-lived cross-protection: CD8 memory lymphocytes can become activated in an antigen-independent fashion by cytokines such as interleukin (IL)-12 and IL-18 that are produced in the initial stages of a secondary infecti”
Why do viruses cause cancer? Highlights of the first century of human tumour virology (2010, background): “In some cases, mammals may even exploit latent viral infections to beneficially regulate their own innate immune system”
Trained immunity: a program of innate immune memory in health and disease (2016, background): “Besides bacterial and fungal pathogens, monocytes/macrophages can also mount trained immunity responses following infection with parasitic (29) and viral (28) pathogens.”
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “For example, mice infected latently with herpesviruses are more resistant to bacterial infections than non-infected mice (Barton et al., 2007).”
Inhibition of pulmonary antibacterial defense by interferon-γ during recovery from influenza infection (2008, result): “In contrast to the acute viral infection examined in this study, chronic viral infection has been reported to induce prolonged production of small amounts of IFN-γ and systemic activation of macrophages, resulting in upregulation of the basal activation state of innate immunity against subsequent ba”