Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin
By P. Zhou, Hang Fan, T. Lan, Xinglou Yang, Wei-feng Shi, Wei Zhang, Yan Zhu, Yawei Zhang, Q. Xie, Shailendra Mani and 34 more. Nature, 2018
707 citations recorded by the source corpus.
Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health1. Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS)2–10. Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms. Notably, the outbreak began in Guangdong province in the vicinity of the origin of the SARS pandemic. Furthermore, we identified SADS-related CoVs with 96–98% sequence identity in 9.8% (58 out of 591) of anal swabs collected from bats in Guangdong province during 2013–2016, predominantly in horseshoe bats (Rhinolophus spp.) that are known reservoirs of SARS-related CoVs. We found that there were striking similarities between the SADS and SARS outbreaks in geographical, temporal, ecological and aetiological settings. This study highlights the importance of identifying coronavirus diversity and distribution in bats to mitigate future outbreaks that could threaten livestock, public health and economic growth. Analysis of viral samples from deceased piglets shows that a bat coronavirus was responsible for an outbreak of fatal disease in China and highlights the importance of the identification of coronavirus diversity and distribution in bats in order to mitigate future outbreaks of disease.
Subfields: Animal Science and Zoology, Infectious Diseases
View Paper: https://www.semanticscholar.org/paper/86dea8c75c56889d8c296ea424d0c257ba690d49
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Citations in the corpus
- Animal models for COVID-19 (2020, background): “By contrast, infection with another bat betacoronavirus—known as swine acute diarrhoea syndrome coronavirus (SADS-CoV)—has been demonstrated in swine 69 .”
- Emerging coronaviruses: Genome structure, replication, and pathogenesis (2020, positive): “For example, in 2016, an HKU2‐related bat CoV, swine acute diarrhea syndrome CoV, caused a large‐scale outbreak of fatal disease in pigs in Southern China, and more than 24 000 piglets were dead.(62) This is the first documented spillover of a bat CoV that caused severe disease in livestock.”
- SARS-CoV-2 and Coronavirus Disease 2019: What We Know So Far (2020, background): “Alpha- and betacoronaviruses infect only mammals, usually causing respiratory symptoms in humans and gastroenteritis in other animals [2,3].”
- The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control (2020, background): “These viruses include IBV in chickens [40], Beluga whale coronavirus SW1 (BWCoV-SW1) [41], bat coronaviruses CDPHE15 and HKU10 (ICTV 2018), porcine epidemic diarrhea virus (PEDV), TGEV, and sudden acute diarrhea syndrome (SADS-CoV) [42].”
- COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives (2020, positive): “Unfortunately, China has seen a number of interspecies transmissions by CoV in recent years [80] [81] [82] .”
- Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study (2020, background): “Coronaviruses are enveloped RNA viruses that could affect birds, humans, and other mammals, leading to respiratory, digestive, hepatic, and nervous system disorders.([4,5]) Among the six coronaviruses known to infect humans, two of them can cause ARDS, which are the severe acute respiratory syndrome”