An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration.

By G. Hageman, P. Luthert, N. V. Chong, L. V. Johnson, Don H. Anderson, R. Mullins. Progress in retinal and eye research, 2001

1,320 citations recorded by the source corpus.

Subfields: Ophthalmology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/86c7ce18534b155a26d769486e8350945900b0e8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Ophthalmology

1. Don H. Anderson
2. L. V. Johnson
3. I. Bhutto
4. G. Lutty
5. G. Hageman
6. O. Strauß

In Radiology, Nuclear Medicine and Imaging

1. O. Strauß
2. L. V. Johnson
3. Don H. Anderson
4. G. Hageman

Citations in the corpus

• Risk factors for the incidence of Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study (AREDS) AREDS report no. 19. (2003, neutral): “AMD category 2 1053 (42) 3a 1453 (58) 4a Neovascular AMD 714 Central GA 74 AREDS treatment Antioxidants 633 (25) 211 (27) Zinc 633 (25) 197 (25) Antioxidants zinc 609 (24) 192 (24) Placebo 631 (25) 188 (24) Demographic and behavioral Age (yrs) 65 548 (22) 122 (15) 65–69 888 (35) 198 (25) 70 1070 (43”
• The retinal pigment epithelium in visual function. (2005, background): “However, a more detailed analysis of the protein composition of Drusen led to alternative theories of Drusen formation (128, 226, 519).”
• Neural remodeling in retinal degeneration. (2003, background): “A recent transgenic model developed by C.-K. Chen (University of Utah) over-expresses the N-terminal domain of RGS9, a retina-specific GTPase accelerator protein and this leads to rapid and complete ARTICLE IN PRESS Table 1 Representative animal models for analysis of neural remodeling Rat LD None D”
• The Impact of Oxidative Stress and Inflammation on RPE Degeneration in Non-neovascular AMD (2017, result): “These observations correlate with the hypothesis made by Hageman et al, in 2001, that drusen are biomarkers of immune-mediated processes at the RPE-Bruch’s membrane triggered by cellular debris and lipids that accumulate in Bruch’s membrane (Hageman et al., 2001).”
• Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts (2006, background): “Remarkably, many patients with MPGNII also develop early onset macular drusen that are clinically, histologically, ultrastructurally and histochemically indistinguishable from ocular drusen in AMD (153).”
• Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex (2012, background): “The reduction in cell density itself may result from apoptosis, which is caused by accumulation of toxic substances (Hageman et al., 2001; Mullins et al., 2000).”
• The Pivotal Role of the Complement System in Aging and Age-related Macular Degeneration: Hypothesis Re-visited (2009, positive): “…have proposed, drusen and other sub-RPE deposits are biomarkers of chronic local inflammation at the RPEechoroid interface (Anderson et al., 2002; Hageman et al., 2001; Johnson et al., 2001), then the recruitment of circulating CRP to the choroid is most likely an indication of cellular injury…”