ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds.

By He Zhao, Jie Huang, Yan Li, Xinjing Lv, Huiting Zhou, Hairong Wang, Yunyun Xu, Chao Wang, Jian Wang, Zhuang Liu. Biomaterials, 2020

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Bacterial infection has been a great threat to dermal wounds, especially to difficult-to-heal diabetic wounds. It is known that reactive oxygen species (ROS) generated by wounds or bacterial infection could further impede wound healing. Here, a type of ROS-scavenging hydrogel is developed by using polyvinyl alcohol (PVA) cross-linked by a ROS-responsive linker. The obtained hydrogel could act as an effective ROS-scavenging agent to promote the wound closure by decreasing the ROS level and up-regulating M2 phenotype macrophages around the wound. Importantly, such hydrogel formed in the wound could allow release of therapeutics, including mupirocin to kill bacteria, and granulocyte-macrophage colony-stimulating factor (GM-CSF) to accelerate the wound closure, in responsive to endogenous ROS existing in the wound microenvironment. Remarkably, our drug-loaded ROS-scavenging hydrogel could be employed to effectively treat various types of wounds including difficult-to-heal diabetic wounds with bacterial infection. Therefore, this work presents an effective strategy based on ROS-scavenging hydrogel for wound healing under various kinds of complications.

Subfields: Endocrinology, Diabetes and Metabolism, Occupational Therapy, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/86c4d096b16f388628fdc62d955a21e89fe14904

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