Adipogenesis and metabolic health

By Alexandra L. Ghaben, P. Scherer. Nature reviews. Molecular cell biology, 2019

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Adipose tissue plasticity in health and disease (2022, background): “Proadipogenic signals include: insulin; bone-morphogenic-protein (BMP) signaling (especially BMP2 and BMP4); and ECM composition (Ghaben and Scherer, 2019).”
Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications (2019, background): “However, recent insights highlight the concept that proper adipose tissue remodeling requires activation of an acute and transient inflammatory response [72].”
Metabolically Healthy Obesity (2020, methodology): “Our data supports models for the development of MUO (60, 61) in which ectopic fat and impaired adipose tissue function may lead to systemic insulin resistance, lipotoxicity, and a proinflammatory state and could, therefore, play a causal role in the transition from MHO to MUO (Fig.”
Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease (2020, background): “, the ability to distribute fat among newly differentiated adipocytes without the need for significant hypertrophy) mitigates such inflammation and subsequent insulin resistance (388).”