Learning and Survival of Newly Generated Neurons: When Time Matters
By A. Mouret, G. Gheusi, M. Gabellec, F. de Chaumont, Jean-Christophe Olivo-Marin, Pierre Marie Lledo. 2008
180 citations recorded by the source corpus.
New interneurons are continually added to the olfactory bulb (OB), the first central relay for processing olfactory information, throughout life. It remains unknown how these adult-generated interneurons integrate into preexisting networks or die. We used immunohistochemical approaches to quantify adult neurogenesis in mice subjected to olfactory training. We identified a critical period in the life of an adult-generated OB interneuron, during which learning triggers distinct consequences. Using a discrimination learning task performed at various times after the birth of new interneurons, we found that olfactory training could increase, decrease, or have no effect on the number of surviving newly generated neurons. Cell survival and elimination depend on both the age of the cell and its location within the granule cell layer. This study provides new insight into the contribution of the newly generated interneurons to OB function. It demonstrates that neuronal elimination is an active process, rather than a simple consequence of nonuse.
Subfields: Developmental Neuroscience, Neurology, Sensory Systems
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Developmental Neuroscience
In Neurology
In Sensory Systems
Citations in the corpus
- Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Neural progeny survival exhibits two critical periods (Figure 3), one at the intermediate progenitor and neuroblast stage (Platel et al., 2010; Sierra et al., 2010) and one at the immature neuron integration stage (Mouret et al., 2008; Tashiro et al., 2006).”
- Neurogenesis Drives Stimulus Decorrelation in a Model of the Olfactory Bulb (2012, background): “It has been found, however, that certain associative odor discrimination tasks can not only enhance but also reduce the survival of the adult-borne granule cells, depending on their age [23].”
- A Critical Time Window for the Recruitment of Bulbar Newborn Neurons by Olfactory Discrimination Learning (2011, background): “However, Mouret et al. (2008) reported that the olfactometer training procedures, where mice learn to lick the reward tube when mineral oil is delivered, did not per se alter neuronal survival.”
- Adult generation of glutamatergic olfactory bulb interneurons (2009, background): “Given the importance of short-axon cells in center-surround inhibition, it can be speculated that the new addition of glutamatergic neurons, as with their GABAergic counterparts, is crucial for modifying the interglomerular circuitry during olfactory discrimination learnin”
- Adult neurogenesis and the olfactory system. (2009, background): “The effects of learning on survival are most pronounced among cells in the deep GCL (Mouret et al., 2008).”