Nrf2 signaling in coordinated activation of antioxidant gene expression.

By Anil K. Jaiswal. Free Radical Biology & Medicine, 2004

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How Do Nutritional Antioxidants Really Work: Nucleophilic Tone and Para-Hormesis Versus Free Radical Scavenging in vivo (2013, positive): “Although a key aspect of Nrf2 activation is its escape from ubiquitinylation and proteasomal degradation, Nrf2 must also be phosphorylated for translocation to the nucleus where it activates EpRE-regulated genes [104, 105].”
Nrf2:INrf2(Keap1) Signaling in Oxidative Stress (2009, neutral): “, Nrf2:INrf2 (Keap1) signa hydrogen peroxide [3].”
Oxidative stress response and Nrf2 signaling in aging. (2015, neutral): “PKCδ has been implicated in Nrf2 translocation [214, 215], but few, if any, of the several studies that have determined the effect of aging on PKC have looked specifically at PKCδ.”
Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex (2004, background): “3 g, lanes 2 to 5), and Cul3(1-380) (from 0.”
GLUTATHIONE SYNTHESIS (2012, background): “Nrf2/MafG heterodimer generally activates ARE-dependent gene transcription and has also been reported to enhance Nrf2 nuclear retention [108,112].”