Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast

By Eduardo M. Torres, T. Sokolsky, C. M. Tucker, Leon Y. Chan, Monica G. Boselli, Maitreya J. Dunham, A. Amon. Science, 2007

945 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Genomic and Functional Approaches to Understanding Cancer Aneuploidy (2018, methodology): “CRISPR-targeting, when combined with an artificial telomerecontaining plasmid, can be used to truncate a chromosome arm (Uno et al., 2017).”
DEPTOR is an mTOR Inhibitor Whose Frequent Overexpression in Multiple Myeloma Cells Promotes their Survival (2009, background): “Elevated DEPTOR expression might be tolerated better in the nonhyperdiploid MMs because aneuploidy itself increases sensitivity to conditions, like mTORC1 inhibition, that interfere with protein synthesis (Torres et al., 2007).”
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction (2009, neutral): “However, they also result in corresponding increases and decreases in transcript levels (Pollack et al., 2002; Torres et al., 2007; Tsafrir et al., 2006) that produce imbalances in the stoichiometry of protein complex subunits (Papp et al.”
Genome evolution across 1,011 Saccharomyces cerevisiae isolates (2018, neutral): “Indeed, cases of aneuploidy arise under a variety of selective regimes but lead to a decrease of global cellular fitness 32–34 .”