Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1

By T. Bivona, I. P. Castro, Ian M Ahearn, Theresa M. Grana, V. Chiu, P. J. Lockyer, P. Cullen, A. Pellicer, A. Cox, M. Philips. Nature, 2003

402 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/8630636a63300d65df742dfea446bf8466845afd

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In Molecular Biology

1. M. McKay
2. DK Morrison

Citations in the corpus

• Integrating signals from RTKs to ERK/MAPK (2007, background): “These second messengers then activate and direct RasGRP1 to the Golgi where it acts on Ras (Bivona et al., 2003).”
• GEFs and GAPs: critical elements in the control of small G proteins. (2007, background): “The importance of proper localization for the biological function of RasGRPs is further demonstrated by the finding that RasGRP1 mediates the activation of Ras at the Golgi (Bivona et al., 2003) and that the localization of RasGRP2 at the plasma membrane is F actin dependent (Caloca et al., 2004).”