Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages.

By Hosoon Choi, R. Lee, N. Bazhanov, J. Oh, D. Prockop. Blood, 2011

638 citations recorded by the source corpus.

Subfields: Genetics, Pulmonary and Respiratory Medicine, Surgery

View Paper: https://www.semanticscholar.org/paper/86182774d06343b4b537290407681283e1a7bdfe

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. A. Keating
2. A. Caplan
3. W. Fibbe
4. Maria Ester Bernardo
5. J. Karp
6. D. Prockop
7. Andrea Augello
8. C. De Bari

In Pulmonary and Respiratory Medicine

1. W. Fibbe
2. Maria Ester Bernardo
3. A. Caplan

In Surgery

1. A. Keating
2. A. Caplan
3. W. Fibbe
4. Maria Ester Bernardo
5. J. Karp

Citations in the corpus

• The secretion profile of mesenchymal stem cells and potential applications in treating human diseases (2022, background): “It was shown that TSG-6 inhibited activation of antigen-presenting cells and T cells in a CD44 dependent manner, consequently blocking insulitis within the pancreas and delaying the onset of type 1 diabetes.235 Similarly, TSG-6 reduces the TLR2/ NF-κB signaling in resident macrophages in the mouse m”
• Mesenchymal stem cell perspective: cell biology to clinical progress (2019, background): “Alternatively, exposure to interferon (IFN)-gamma licenses the immunosuppressive activity of MSCs by inducing expression of indoleamine 2,3-dioxygenase (IDO1), an enzyme in the kynurenin pathway that consumes tryptophan(55,56) resulting in reduced inflammation, and stimulation by TNF upregulates exp”
• Mesenchymal stromal cells: sensors and switchers of inflammation. (2013, positive): “On the same line, in a zymosan-induced peritonitis model, infusion of human BM- MSCs resulted in secretion of TNF-stimulated gene 6 (TSG6), a molecule that interferes with TLR2 nuclear factor-kB (NF-kB) signaling in peritoneal macrophages, thereby attenuating their activation (Choi et al., 2011).”
• Mesenchymal stromal cells: new directions. (2012, background): “Several recent studies have identified pathways that are involved, including downregulation of NF-kB signaling and cell cycle arrest at G0/G1 (Jones et al., 2007; Choi et al., 2011).”
• Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation (2014, background): “In the ten most highly interconnected genes, we identified FABP5, which has recently been implicated in lipid metabolism and inflammation crosstalk (Furuhashi et al., 2011), and TNFAIP6, a negative feedback regulator of myeloid cell activation (Choi et al., 2011).”