The evolution and evolutionary consequences of marginal thermostability in proteins

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Relationship between protein thermodynamic constraints and variation of evolutionary rates among sites (2014, background): “…level (Drummond & Wilke 2008, Serohijos et al. 2012), the evolution of novel function (Bloom et al. 2006, Tokuriki et al. 2008), and the expected equilibrium distributions of stability and the explanation of marginal stability (Taverna & Goldstein 2002, Goldstein 2011, Wylie & Shakhnovich 2011).”
Merging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population genetics (2014, background): “In a GPR based on protein folding stability, and under the assumption that the protein folding thermodynamics is two-state [7,8,18], the selection coef-ﬁcient upon a mutation can be approximately expressed as [11,12,15] s (cid:4) e b D G wildty pe ð 1 (cid”
Selection for Protein Stability Enriches for Epistatic Interactions (2018, background): “The mean of this distribution is only slightly negative, 103 indicating that the evolved proteins are marginally stable, as predicted by theory and observed in 104 nature [8,11,29,31,32].”