Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer.

By A. Fyles, D. McCready, L. Manchul, M. Trudeau, P. Merante, M. Pintilie, L. Weir, I. Olivotto. New England Journal of Medicine, 2004

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Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. (2015, background): “In patients >70 years of age who have endocrine-responsive invasive breast cancer with maximum stage pT1N0 and clear margins, it may be possible to omit radiation therapy without compromising survival [II, B] [36, 48].”
Advances in Radiation Therapy: Conventional to 3D, to IMRT, to 4D, and Beyond (2005, background): “The key questions are: can we shorten the duration of standard breast irradiation, can we treat a portion of the breast instead of the whole, and can we select women who can avoid radiotherapy altogether? The issue of avoiding radiotherapy in BCT has been explored in the past and recently revisited ”
Meeting highlights: international expert consensus on the primary therapy of early breast cancer 2005. (2005, background): “Radiation therapy may not be necessary after conservative surgery in selected elderly patients (over 70 years) with small endocrine responsive cancer whose tumor excision was complete and who receive tamoxifen, although long-term follow up is not yet available [143, 144].”