Structure of a DNA-bound Ultrabithorax–Extradenticle homeodomain complex

By J. Passner, H. Ryoo, Leyi Shen, R. Mann, A. Aggarwal. 1999

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Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior. (2003, background): “4C; Passner et al. 1999; Piper et al. 1999).”
Functional specificity of a Hox protein mediated by the recognition of minor groove structure. (2007, unknown): “…are typically disordered in the existing NMR and crystal structures (Billeter et al., 1993; Fraenkel and Pabo, 1998; Fraenkel et al., 1998; Hirsch and Aggarwal, 1995; Hovde et al., 2001; Li et al., 1995; Passner et al., 1999; Piper et al., 1999; Tucker-Kellogg et al., 1997; Wolberger et al., 1991).”
Origins of specificity in protein-DNA recognition (2010, unknown): “Notable examples are Hox-Exd/Pbx heterodimers (28, 29, 214), the MATa1-MATα2 heterodimer (144), and the NFAT-Fos-Jun heterotrimer (215).”
Crystal structure of ATF‐2/c‐Jun and IRF‐3 bound to the interferon‐β enhancer (2004, background): “Some cooperativity is retained even after removal of a small interacting loop of Ultrabithorax, which inserts into a hydrophobic pocket on the Extradenticle homeodomain surface (Passner et al, 1999).”