Advances and Challenges of Liposome Assisted Drug Delivery
By Lisa Sercombe, Tejaswi Veerati, F. Moheimani, S. Wu, Anil Sood, S. Hua. Frontiers in Pharmacology, 2015
2,224 citations recorded by the source corpus.
The application of liposomes to assist drug delivery has already had a major impact on many biomedical areas. They have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and improving biodistribution of compounds to target sites in vivo. This enables effective delivery of encapsulated compounds to target sites while minimizing systemic toxicity. Liposomes present as an attractive delivery system due to their flexible physicochemical and biophysical properties, which allow easy manipulation to address different delivery considerations. Despite considerable research in the last 50 years and the plethora of positive results in preclinical studies, the clinical translation of liposome assisted drug delivery platforms has progressed incrementally. In this review, we will discuss the advances in liposome assisted drug delivery, biological challenges that still remain, and current clinical and experimental use of liposomes for biomedical applications. The translational obstacles of liposomal technology will also be presented.
Subfields: Biomaterials, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/5918fdf696704872bcbee1bf8e66258fb50e2150
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Citations in the corpus
- Liposomes: structure, composition, types, and clinical applications (2022, background): “Liposomes were firstly discovered in the 1960's by Bengham and later became among the most expansive drug delivery systems [14].”
- Controlled Drug Delivery Systems: Current Status and Future Directions (2021, background): “These are the colloidal particles formed by combining the amphiphilic phospholipids that enclose an aqueous compartment surrounded by lipid bilayers [77].”
- Therapeutic Nanoparticles and Their Targeted Delivery Applications (2020, background): “The neutral or positively charged small liposomes have higher circulation time when compared to large, unmodified liposomes [74].”