Immune responses to implants - a review of the implications for the design of immunomodulatory biomaterials.

By S. Franz, S. Rammelt, D. Scharnweber, J. Simon. Biomaterials, 2011

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Multifunctional Coatings to Simultaneously Promote Osseointegration and Prevent Infection of Orthopaedic Implants (2016, neutral): “In addition to speeding up tissue regeneration ([148]), immunomodulation can also be used to prime or tri gger the body’s innate immune system, and hence indirectly prevent infections.”
Biomaterials of Poly(vinyl alcohol) and Natural Polymers (2018, background): “For example, proteins of animal origin are known for their inherent immunogenicity and they might determine the increase of inflammatory response or cause allergic reactions for the host.(195) Consequently, high purification Table 1.”
Titanium Surface Characteristics, Including Topography and Wettability, Alter Macrophage Activation (2015, background): “However, a lack of inflammatory response will leave the debris from implantation to remain and affect the integration of the material and generation of new tissue [6, 7].”
The Role of Macrophage Phenotype in Vascularization of Tissue Engineering Scaffolds (2014, neutral): “[66], caution should be exercised in generalizing the results of macrophage response to the scaffolds studied in the present work to that of other biomaterials.”
Biomaterial based modulation of macrophage polarization: A review and suggested design principles (2015, background): “Historically, such implants were preferred to be biologically inert, to minimize interactions between the implant and cells in the microenvironment [86].”