Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets.

By C. Ramassamy. European Journal of Pharmacology, 2006

693 citations recorded by the source corpus.

Subfields: Complementary and alternative medicine, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/8535e9fe8887d28d1c5acb5d614d0c85e0e49c97

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Complementary and alternative medicine

1. W. Routray
2. D. Kennedy
3. E. Wightman
4. V. Orsat

In Neurology

1. W. Routray
2. D. Kennedy
3. E. Wightman
4. V. Orsat

In Physiology

1. W. Routray
2. D. Kennedy
3. E. Wightman
4. V. Orsat

Citations in the corpus

• BRAIN FUEL METABOLISM, AGING AND ALZHEIMER’S DISEASE (2010, background): “Increased free radical release leading to peroxidative damage is also seen in the AD brain [110,111] and in epidemiologic studies [112], so it is possible that disrupted mitochondrial function in AD prevents the appropriate balance between production and destruction of free radicals, leading to furt”
• Herbal extracts and phytochemicals: plant secondary metabolites and the enhancement of human brain function. (2011, background): “Despite a wealth of in vitro and in vivo animal evidence, to date there is lack of evidence of clinical benefits in humans, leaving open the issues of bioavailability and biotransformation (231).”
• Oxidative Stress: A Key Modulator in Neurodegenerative Diseases (2019, background): “Heavy metals are directly or indirectly involved in the generation of ROS/RNS and lead to oxidative stress, which ultimately deteriorates the mitochondria and biomolecules, leading to cell proliferation, cell differentiation, and apoptosis [50].”
• Role of carnitine in disease (2010, background): “Based on the evidence that heat-shock proteins (Hsps) can exert neuroprotective effects against oxidative stress-related injury and that nutritional antioxidants are able to upregulate Hsps in neurons, use of nutritional antioxidants such as carnitine/acetyl-L-carnitine has been advocated to counter”
• Blueberries and Their Anthocyanins: Factors Affecting Biosynthesis and Properties (2011, background): “Other antioxidants along with anthocyanins present in blueberries can also be helpful against neurodegenerative disorders (Ramassamy 2006).”