Brain hydrogen sulfide is severely decreased in Alzheimer's disease.

By K. Eto, T. Asada, K. Arima, T. Makifuchi, H. Kimura. Biochemical and Biophysical Research Communications - BBRC, 2002

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Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders. (2003, background): “SAM levels have been found to be low in the cerebral spinal fluid and brains of individuals with several neurological disorders, including AD [ 83 ,84].”
The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite ‘scavenger’? (2004, methodology): “In rat hippocampal slices, H2S production from CBS is regulated by Ca2+/calmodulin and is enhanced by L-glutamate, NMDA and AMPA and inhibited by AP-5 and CNQX, suggesting the involvement of at least two classes of ionotropic glutamate receptors in H2S production (Eto et al. 2002a).”
Role of ROS and RNS Sources in Physiological and Pathological Conditions (2016, background): “2 S levels are lowered in Alzheimer’s disease, a neurological disorder [433]:”
Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. (2012, background): “In Alzheimer’s disease, the brain’s H2S concentration was found to be severely decreased, which led to a theory that H2S may be be the limiting factor for the development of this disease (167).”
A two-photon fluorescent probe for imaging hydrogen sulfide in living cells (2013, background): “Altered levels of H2S have been linked to many diseases, such as Alzheimer’s disease, Down’s syndrome, diabetes and liver cirrhosis[4-6].”