Transcriptional activation of miR-34a contributes to p53-mediated apoptosis.

By Nina Raver-Shapira, E. Marciano, E. Meiri, Y. Spector, N. Rosenfeld, N. Moskovits, Z. Bentwich, Moshe Oren. Molecules and Cells, 2007

1,412 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/84a37442f8d81fe991980153b9280c1fd1f52a8d

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Citations in the corpus

MicroRNAs in development and disease. (2011, background): “Moreover, a p53 enhancer that is in close proximity to the 5=-end of the miR-34a primary transcript is located in a CpG island (503).”
miR-34 – a microRNA replacement therapy is headed to the clinic (2012, background): “This anti-oncogenic activity of miR-34a has been demonstrated in cancer cell types of lung (Bommer et al., 2007; He et al., 2007; Raver-Shapira et al., 2007; Tarasov et al., 2007; Sun et al., 2008; Wiggins et al., 2010), liver (Li et al., 2009), pancreas (Lodygin et al., 2008; Ji et al., 2009),…”
Causes and consequences of microRNA dysregulation in cancer (2009, background): “pl?acc=MI0000743"> miR-34c ) is induced directly by the p53 tumour suppresso”
MicroRNAs in stress signaling and human disease (2012, background): “…the miR-34a and miR-34b/miR-34c transcription units which then are able to mediate some aspects of the cellular response to p53 activation, including cell-cycle arrest and apoptosis (Bommer et al., 2007; Chang et al., 2007; He et al., 2007; Raver-Shapira et al., 2007; Tarasov et al., 2007).”
Therapeutic delivery of miR-26a inhibits cancer cell proliferation and induces tumor-specific apoptosis (2009, positive): “…that express miR-18a, a component of the protumorigenic miR-17-92 cluster, and miR-34a, which is known to have potent antiproliferative and proapoptotic activity in other cell lines (Bommer et al., 2007; Chang et al., 2007; He et al., 2007a; Raver-Shapira et al., 2007; Tarasov et al., 2007).”
MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells (2009, positive): “Our data are consistent with the reported tumor suppressor function of miR-34 [6,8,9,11,22].”
Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies (2016, background): “Notably, numerous miRNAs are also transcriptionally modulated by wtp53 [174] and among them is miR-34a [175,176], a member of the MiR-34 family implicated in cell death/survival signaling.”