RNA virus error catastrophe: Direct molecular test by using ribavirin

By Shane Crotty, C. Cameron, Raul Andino. Proceedings of the National Academy of Sciences of the United States of America, 2001

865 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/849bbc4dcaa6652b84cfb35cdf76ab726ab31f93

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Edward C. Holmes
2. Siobain Duffy
3. Miguel Angel Muñoz
4. Rafael Sanjuán
5. Raul Andino
6. L. A. Shackelton
7. A. Lauring

In Molecular Biology

1. Siobain Duffy
2. Edward C. Holmes
3. Miguel Angel Muñoz
4. Rafael Sanjuán
5. Nicola Chirico
6. L. A. Shackelton
7. David S. Wishart
8. Jeremy K. Nicholson

In Plant Science

1. Edward C. Holmes
2. Siobain Duffy
3. Miguel Angel Muñoz
4. Raul Andino

Citations in the corpus

• Colloquium: Criticality and dynamical scaling in living systems (2017, background): “It was conjectured (Drake and Holland, 1999; Eigen, 2002; Solé et al., 1999, 1996) and has been (partially) verified in recent experiments (Crotty et al., 2001; Hart and Ferguson, 2015) that RNA viruses might operate right at the edge of the catastrophe, providing them with maximal variability…”
• Viral Mutation Rates (2010, background): “This strategy, called lethal mutagenesis, has proved effective in cell cultures or animal models against several RNA viruses, including enteroviruses (11, 39, 44), aphtoviruses (83), vesiculoviruses (44), hantaviruses (10), arenaviruses (40), and lentiviruses (15, 53), and appears to at least partly”
• Why are RNA virus mutation rates so damn high? (2018, background): “The exogenous A fitness landscape showing three genotypes on different places on the landscape (A, B, and C) and a schematic pie chart of the distribution of mutations available to each genotype.”
• Quasispecies Theory and the Behavior of RNA Viruses (2010, background): “Ribavirin, a nucleoside with broad antiviral activity, has attracted considerable interest, and can induce lethal mutagenesis of Hantaan virus and poliovirus [42,43,59].”
• Rates of evolutionary change in viruses: patterns and determinants (2008, background): “For example, a 10-fold increase in mutation rate reduced poliovirus titres 1,000-fol”
• Review. Elimination of viruses in plants: twenty years of progress (2013, background): “Moreover, ribavirin’s antiviral effect is by forcing RNA viruses into error catastrophe (Crotty et al., 2001).”