Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall

By K. Nakazawa, M. Quirk, R. A. Chitwood, Masahiko Watanabe, M. Yeckel, L. D. Sun, Akira Kato, Candice A. Carr, D. Johnston, Matthew A. Wilson and 1 more. Science, 2002

1,120 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/84500eaf9569a06ce654fb3ee6d584fb90b57960

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Hippocampal CA3 Output is Crucial for Ripple-Associated Reactivation and Consolidation of Memory (2009, neutral): “There was no difference between genotypes in the mean firing rate of pyramidal cells, in the Complex Spike Index (CSI; a measure of bursting (Nakazawa et al., 2002)) or in the mean burst length, although there was a small decrease in the fraction of spikes participating in bursts in the mutant…”
Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABAA Receptors Reduces Memory Interference (2015, background): “…the more recent, CS memory regardless of the contextual cues, suggesting additional experiments taking into account that variables, such as the extent of context dependence of different memories (Bouton, 1993; Nelson, 2002), may be required to clarify the results of this specific experiment.”
CA3 Retrieves Coherent Representations from Degraded Input: Direct Evidence for CA3 Pattern Completion and Dentate Gyrus Pattern Separation (2014, background): “…shown evidence consistent with a pattern separation function in both DG and CA3 and a pattern completion function in CA3 (e.g., Gilbert et al., 2001; Rolls and Kesner, 2006; Kesner et al., 2000; McHugh et al., 2007; Nakazawa et al., 2002; Lee et al., 2004; for review, see Yassa and Stark, 2011).”
A computational theory of hippocampal function, and empirical tests of the theory. (2006, background): “However, if completion from an incomplete cue is needed, then CA3 NMDA receptors are necessary (presumably to ensure satisfactory CA3–CA3 learning) even in a reference memory task (Nakazawa et al., 2002).”
Elements of a neurobiological theory of hippocampal function: the role of synaptic plasticity, synaptic tagging and schemas (2006, background): “Recent results also suggest that plasticity in associative synapses of CA3 is necessary for the successful encoding of spatial information in a manner that later allows recall with partial cues (Nakazawa et al., 2002).”
Synaptic plasticity, memory and the hippocampus: a neural network approach to causality (2008, background): “, animals can perform these tasks as well as control littermates if the NR1 deletion is confined to pyramidal cells in area CA3 (Ref”
Pattern separation, completion, and categorisation in the hippocampus and neocortex. (2016, background): “…E.T. Rolls / Neurobiology of Learning and Memory xxx (2015) xxx–xxx (as shown by the evidence from CA3-specific vs CA1-specific NMDA receptor knockouts) (Nakazawa et al., 2002, 2003, 2004; Rondi-Reig, Libbey, Eichenbaum, & Tonegawa, 2001).”
Using immediate-early genes to map hippocampal subregional functions. (2007, methodology): “Although these methods have been used to assess the contribution of NMDA receptors to CA3 function (Nakazawa et al. 2002, 2003; Cravens et al. 2006; Rajji et al. 2006), the behavioral consequences of targeted knockout/ knockdown of a specific IEG in CA3 has not yet been reported.”