Maternal vitamin D status during pregnancy and child outcomes
By C. Gale, Siân M. Robinson, Nicholas C. Harvey, M. K. Javaid, B. Jiang, C. Martyn, Keith M. Godfrey, C. Cooper. European Journal of Clinical Nutrition, 2007
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Objective:To investigate whether exposure to high maternal concentrations of 25(OH)-vitamin D in pregnancy poses any risk to the child.Design:Prospective study.Setting:Princess Anne Maternity Hospital, Southampton, UK.Subjects:A group of 596 pregnant women were recruited. A total of 466 (78%) children were examined at birth, 440 (74%) at age 9 months and 178 (30%) at age 9 years.Methods:Maternal 25 (OH)-vitamin D concentrations were measured in late pregnancy. Anthropometry of the child was recorded at birth, 9 months and 9 years. At 9 months, atopic eczema was assessed. At 9 years, children had an echocardiogram and a dual energy x-ray absorptiometry scan, blood pressure, arterial compliance and carotid intima-media thickness were measured and intelligence and psychological function assessed.Results:There were no associations between maternal 25(OH)-vitamin D concentrations and the child's body size or measures of the child's intelligence, psychological health or cardiovascular system. Children whose mothers had a 25(OH)-vitamin D concentration in pregnancy >75 nmol/l had an increased risk of eczema on examination at 9 months (OR 3.26, 95% CI 1.15–9.29, P=0.025) and asthma at age 9 years (OR 5.40, 95% CI, 1.09–26.65, P=0.038) compared to children whose mothers had a concentration of <30 nmol/l.Conclusion:Exposure to maternal concentrations of 25(OH)-vitamin D in pregnancy in excess of 75 nmol/l does not appear to influence the child's intelligence, psychological health or cardiovascular system; there could be an increased risk of atopic disorders, but this needs confirmation in other studies.Sponsorship:The study was supported by the Medical Research Council and WellChild (previously known as Children Nationwide).
Subfields: Health, Toxicology and Mutagenesis, Pathology and Forensic Medicine, Public Health, Environmental and Occupational Health
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Citations in the corpus
- Vitamin D for Health: A Global Perspective (2013, neutral): “One recent study found that higher maternal serum 25(OH)D levels in late pregnancy (<12 vs >30 ng/mL) were associated with larger head circumference of offspring at 9 years old but not withmeasures of cognition or psychological health.(5,194) In addition, there may be a critical window during late g”
- The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. (2012, result): “For childhood asthma and allergy, some studies found that higher maternal intake of vitamin D during pregnancy decreased the risk (328, 329), whereas other studies found that higher maternal 25(OH)D levels during pregnancy increased the risk as much as 5-fold (330, 331).”