Genes and Signals

By M. Ptashne, A. Gann. 2001

441 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

On schemes of combinatorial transcription logic (2003, background): “This architecture of the regulatory system makes it very evolvable (10, 22), because it is straightforward to modify individual DNA-binding sequences (through point substitutions), adjust their positions within a regulatory region (via insertions and deletions), and move (cid:2) copy them from one…”
Transcription Factors Bind Thousands of Active and Inactive Regions in the Drosophila Blastoderm (2008, background): “These proteins mediate transcription by binding in a sequence-specific manner to cis-regulatory modules (CRMs) found throughout the nonprotein coding portions of animal genomes (reviewed in [4-7]).”
How do site-specific DNA-binding proteins find their targets? (2004, background): “For instance, to understand the dynamics of gene regulation and thus the responses of cells and organisms to changes in their environments, it is necessary to understand how small numbers of transcription factors are transported to speci®c sites so as to allow reasonable response times for the activ”
Deciphering the transcriptional histone acetylation code for a human gene. (2002, unknown): “Hassan et al., 2001; Ptashne and Gann, 2002).”