Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

By Les Dethlefsen, David A. Relman. Proceedings of the National Academy of Sciences of the United States of America, 2010

2,267 citations recorded by the source corpus.

Subfields: Epidemiology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/83d3e61a7b5cc4821a031b5c486b1810aa3b2501

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Citations in the corpus

Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications. (2012, background): “Many recent studies of the role of the microbiome in human health follow the dynamics of microbial communities (Dethlefsen and Relman, 2011; Frank et al., 2010; Hartman et al., 2009; Human Microbiome Project Consortium, 2012a, 2012b; Morowitz et al., 2011).”
Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients (2017, background): “Thus, while an individual gut microbiome can remain stable for long periods of time, antibiotics [37] and diet changes [38] can rapidly alter the gut microbiome.”
Starving our Microbial Self: The Deleterious Consequences of a Diet Deficient in Microbiota-Accessible Carbohydrates (2014, positive): “Externally applied forces, such as diet or antibiotics, result in rapid alterations of the microbiota, thereby affecting the status of host-microbiota relations (David et al., 2014; Dethlefsen et al., 2008; Dethlefsen and Relman, 2010; Walker et al., 2011).”
Xenobiotics shape the physiology and gene expression of the active human gut microbiome (2013, positive): “In particular, exposure to xenobiotics such as antibiotics and host-targeted drugs seemed likely candidates given their longlasting influence on the composition of the gut microbiota (Dethlefsen and Relman, 2011; Jernberg et al., 2010).”
Moving pictures of the human microbiome (2011, background): “Taken together, our observations paint a picture of a human microbiome that is highly variable over time (Figures 2 and 3; Additional files 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15), but from which stable patterns of similarities and differences among body habitats and individuals emerge…”
Reduced Incidence of Prevotella and Other Fermenters in Intestinal Microflora of Autistic Children (2013, neutral): “Notably, in a recent paper by Dethlefsen and Relman [68], Prevotella, one of the significant genera observed here, was re-established back to pre-antibiotic levels within one month after ciprofloxacin treatment.”
Core microbiomes for sustainable agroecosystems (2018, background): “Even if shifts from unfavourable (host-damaging) microbiome types occur as consequences of large perturbation (for example, antibiotic or fungicide treatment), such shifts would often result in unexpected fluctuations of microbiome structure 43,44 .”
Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders (2015, background): “Antibiotics can also alter the diversity of the composition of the gut microbiota (Dethlefsen and Relman, 2011; Willing et al., 2011) with potential implications for neurochemistry and behavior (Bercik and Collins, 2014).”
The healthy human microbiome (2016, background): “Antibiotics also cause a drastic reduction in the diversity of the microbiome with highly variable recovery dynamics [107], potentially weakening the community’s ability to exclude pathogens.”