Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model.

By C. Foged, B. Brodin, S. Frokjaer, A. Sundblad. International journal of pharmaceutics, 2005

869 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/83cbdc24cbb67bd34f13885d323c6b2cc7e4fcf3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Molecular Biology

Citations in the corpus

Delivering nanomedicine to solid tumors (2010, background): “In addition, researchers have found both experimentally and with the use of mathematical modeling that internalization is maximized for a range of particle sizes”
An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites (2019, background): “[75] Nucleus targeting was investigated with different imaging probes like magnetic nanoparticles,[76] AuNPs,[77–79] AgNPs[80,81] and QDs.[82] Biologically, to deliver the payload drug targeted NPs to the nucleus, they are subjected to bypass a number of barriers such as (1) the cell membrane, (2) a”
PLGA-based nanoparticles: an overview of biomedical applications. (2012, background): “Positively charged nanoparticles seem to allow higher extent of internalization, apparently as a result of the ionic interactions established between positively charged particles and negatively charged cell membranes [11,12].”
Nanomaterial cytotoxicity is composition, size, and cell type dependent (2010, result): “rod) between materials of the same composition will likely yield size/shape dependent in vitro and in vivo cellular responses as shown in previous studies [88-93].”
Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. (2010, background): “Particle size and surface charge can affect the efficiency and pathway of cellular uptake for liposomes [4], quantum dots [5], polymeric NPs [6,7], gold NPs [8], and silica NPs [2] by influencing the adhesion of the particles and their interaction with cells [9].”