Epigenetic Regulation by Long Noncoding RNAs

By Jeannie T. Lee. Science, 2012

1,245 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/838a1e5ba697fa117564d65c12adc93a247b1da8

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In Cancer Research

In Molecular Biology

Citations in the corpus

The Xist lncRNA exploits three-dimensional genome architecture to spread across the X-chromosome (2013, background): “The Xist ncRNA provides a model to investigate the mechanisms of lncRNA localization (11, 18, 19).”
Transcriptional Regulation and its Misregulation in Disease (2013, positive): “Many of the ncRNAs contribute to control of gene expression through modulation of transcriptional or post-transcriptional processes (Bartel, 2009; Ebert and Sharp, 2012; Lee, 2012; Orom and Shiekhattar, 2011; Rinn and Chang, 2012; Wright and Ciosk, 2012).”
Chapter Five – Progress Towards RNAi-Mediated Insect Pest Management (2014, background): “Long non-coding RNAs also play a prominent role in the epigenetic regulation of gene expression (Lee, 2012).”
X-inactivation, imprinting, and long noncoding RNAs in health and disease. (2013, background): “It has been argued that lncRNAs make ideal factors for allelic regulation (Lee, 2012).”
A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis. (2015, background): “…of lncRNAs have been characterized functionally, and most of them are shown to control gene expression by regulating various aspects of gene expression (Ankö and Neugebauer, 2010; Carrieri et al., 2012; Gong and Maquat, 2011; Hung et al., 2011; Lee, 2012; Wang et al., 2011; Yoon et al., 2012).”
Comprehensive Genomic Characterization of Long Non-Coding RNAs across Human Cancers (2015, background): “LncRNAs can serve as scaffolds or guides to regulate protein-protein or protein-DNA interactions, as decoys to bind proteins or microRNAs (miRNAs), and as enhancers to influence gene transcription, when transcribed from enhancer regions or their neighboring loci (Batista and Chang, 2013; Guttman and”