Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies
By Y. Qing, Lin Cheng, Ruiyan Li, Guancong Liu, Yanbo Zhang, Xiongfeng Tang, Jincheng Wang, He Liu, Yanguo Qin. International Journal of Nanomedicine, 2018
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Infection, as a common postoperative complication of orthopedic surgery, is the main reason leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising antibacterial agent and always used to modify orthopedic implants to prevent infection. To optimize the implants in a reasonable manner, it is critical for us to know the specific antibacterial mechanism, which is still unclear. In this review, we analyzed the potential antibacterial mechanisms of AgNPs, and the influences of AgNPs on osteogenic-related cells, including cellular adhesion, proliferation, and differentiation, were also discussed. In addition, methods to enhance biocompatibility of AgNPs as well as advanced implants modifications technologies were also summarized.
Subfields: Biomedical Engineering, Materials Chemistry
View Paper: https://www.semanticscholar.org/paper/96d6352749340bf84e9ecc010e114e703d103436
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Citations in the corpus
- Metal-Based Nanoparticles as Antimicrobial Agents: An Overview (2020, background): “complexes with nucleic acids between the purine and pyrimidine base pairs, disrupting H-bonds between them [96].”
- Silver Nanoparticles and Their Antibacterial Applications (2021, background): “However, all of these mechanisms do not affect AgNPs action, as was established in Section 3, AgNPs act on bacterial cells by different simultaneous mechanisms that include diffusion of small AgNPs and Ag ions into the cell, disruption and mechanical damage on cell membranes, and alteration of prote”
- Silver nanoparticles: Synthesis, medical applications and biosafety (2020, background): “It is observed that AgNPs can anchor and then penetrate the bacterial membrane, and subsequently trigger the destruction of cell membrane and leakage of content [187].”