Phospholipase A2 isoforms: a perspective

By S. Chakraborti. 2003

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Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model (2019, background): “Second, lipid peroxidation during ferroptosis is a deleterious process, and one way to repair such damage is to remodel lipids, by selectively cleaving the oxidized PUFA tail, replacing it with non-oxidized fatty acids, and subsequently reducing lipid hydroperoxides with GSH peroxidase (Chakraborti,”
Vitamin E, antioxidant and nothing more. (2007, background): “If PLA2 activation in a given model depends on PKC, PKA, cAMP, or MAPK then inhibition of these phosphorylating enzymes may alter activities of PLA2 isoforms during cellular injury [101], thus explaining the antioxidant role of α-tocopherol in signaling pathways.”