The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A

By M. Weisser, Felix Voigts-Hoffmann, J. Rabl, M. Leibundgut, N. Ban. 2013

88 citations recorded by the source corpus.

Subfields: Molecular Biology

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In Molecular Biology

1. A. Hinnebusch
2. M. Sokabe
3. I. S. Fernández
4. C. Fraser
5. W. Merrick
6. G. Pavitt
7. J. Lorsch
8. V. Ramakrishnan

Citations in the corpus

• Protein Synthesis Initiation in Eukaryotic Cells. (2018, background): “Their cooperative binding induces conformational changes that rotate the head and open up a cleft between the head and body of the 40S to facilitate TC binding (Maag et al. 2005; Passmore et al. 2007; Weisser et al. 2013; Sokabe and Fraser 2014).”
• Toward a Kinetic Understanding of Eukaryotic Translation. (2018, background): “However, other initiation components may contribute to stabilizing this conformation because structures of 40S subunit complexes that include eIF1 and eIF1A adopt a closed conformation (Hashem et al. 2013; Lomakin and Steitz 2013; Weisser et al. 2013).”
• Structural Insights into the Mechanism of Scanning and Start Codon Recognition in Eukaryotic Translation Initiation. (2017, background): “The eIF1A NTT Stabilizes the Codon–Anticodon Helix The globular domain of eIF1A binds to the 40S A site, as demonstrated by DHRC mapping in mammalian PICs [41] and crystal structures of 40S–eIF1–eIF1A complexes from Tetrahymena [42] and mammals [35].”
• Structural Changes Enable Start Codon Recognition by the Eukaryotic Translation Initiation Complex (2014, methodology): “thermophila (Weisser et al., 2013) (Figure S4C) allowed us to build and refine the structure and use it in subsequent analysis.”
• The scanning mechanism of eukaryotic translation initiation. (2014, methodology): “The NMR structures of human eukaryotic initiation factor 1A (eIF1A) (PDB 1D7Q) ( purple) and Tetrahymena eIF1 (PDB 2XZM) (red ) were docked on the 40S subunit in the analogous positions observed in the 30S/eIF1 complex (PDB 1HR0) and the 40S/eIF1 complex (PDB 2XZM), respectively. aIF2β (orange) was ”