A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma.
By R. Jenkins, H. Blair, K. Ballman, C. Giannini, R. Arusell, M. Law, H. Flynn, S. Passe, Sara J. Felten, P. Brown and 2 more. Cancer Research, 2006
723 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/fbde5a18211531358c3edb813e2b4431910f165d
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Citations in the corpus
- Glioma Subclassifications and Their Clinical Significance (2017, background): “More recent studies determined that the co-deletion of these 2 chromosomal arms is due to a balanced translocation between chromosomes 1 and 19 and subsequent loss of other chromosomal arms [25].”
- High-grade glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. (2014, background): “Genetic loss on chromosomes 1p/19q (co-deletion or loss of heterozygosity [LOH] 1p/19q) is a consequence of a chromosomal translocation and describes a distinct tumour entity characterised by a prolonged natural history irrespective of treatment, and increased sensitivity both to radiotherapy (RT) a”
- Genetics of adult glioma. (2012, background): “The most common genetic anomaly and genetic characteristic of oligodendroglioma and mixed oligoastrocytoma is the codeletion of chromosome arms 1p and 19q (45,46), which is mediated by an acquired 1;19 translocation (47,48).”