Heme oxygenase-1: unleashing the protective properties of heme.

By L. Otterbein, M. Soares, K. Yamashita, F. Bach. Trends in immunology, 2003

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The therapeutic potential of carbon monoxide (2010, background): “HMOX1 is one of the most sensitive genes described in nature so far; it can be stimulated by an array of conditions that are associated with a moderate or a persistent imbalance of the intracellular redox stat”
Nitric oxide and redox mechanisms in the immune response (2011, neutral): “dants, biliverdin and CO [205].”
Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders (2010, neutral): “However, in these experimental conditions, inhibition of HO activity or ablation of gene expression for HO-1 causes acute rejection, unless the donor and recipient received CO at a concentration of 250ppm, similar to that found in heavy smokers, in which case grafts survive indeﬁnitely (338).”
Egg coloration is correlated with female condition in eastern bluebirds (Sialia sialis) (2006, background): “Biliverdin is a porphyrin that results from oxidative degradation of heme (Lemberg and Legge 1949; Otterbein et al. 2003).”
Role of Glutathione in Cancer Progression and Chemoresistance (2013, background): “It catalyzes the rate-limiting step in the catabolism of the prooxidant heme to carbon monoxide, biliverdin, and free iron [85].”