The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy
By Q. Xie, W. Bu, S. Bhatia, J. Hare, T. Somasundaram, A. Azzi, M. Chapman. Proceedings of the National Academy of Sciences of the United States of America, 2002
628 citations recorded by the source corpus.
Subfields: Genetics, Infectious Diseases, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8229724c663bf9040f51fd2877671595d90f6fac
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Genetics
In Molecular Biology
Citations in the corpus
- Immune responses to AAV vectors: overcoming barriers to successful gene therapy. (2013, neutral): “9 The gene is the active agent of the therapeutic, but the vector, in most cases derived from a virus, is also a critical determinant of therapeutic success and of the toxicity pro fi le of the product.”
- Progress and problems with the use of viral vectors for gene therapy (2003, background): “The recent determination of the crystal structure of the AAV2 capsid might facilitate this type of approach in the futur”
- Adeno-associated virus serotypes: vector toolkit for human gene therapy. (2006, methodology): “To date, the crystal structure of AAV2 has been determined at a resolution of 3 2 using X-ray crystallography [104], while the structures of AAV4 and 5 have been solved using cryoelectron microscopy (cryo-EM) and image reconstruction at a resolution of 13 and 16 2, respectively [105,106].”
- Virus entry: molecular mechanisms and biomedical applications (2004, background): “Understanding the structure of AAV 105 and other viruses could help to further improve the specificity and efficiency of retargeting.”