Leptin Regulates Striatal Regions and Human Eating Behavior

By I. S. Farooqi, E. Bullmore, J. Keogh, J. Gillard, S. O’Rahilly, Paul C. Fletcher. Science, 2007

611 citations recorded by the source corpus.

Studies of the fat-derived hormone leptin have provided key insights into the molecular and neural components of feeding behavior and body weight regulation. An important challenge lies in understanding how the rewarding properties of food interact with, and can override, physiological satiety signals and promote overeating. We used functional magnetic resonance imaging to measure brain responses in two human patients with congenital leptin deficiency who were shown images of food before and after 7 days of leptin replacement therapy. Leptin was found to modulate neural activation in key striatal regions, suggesting that the hormone acts on neural circuits governing food intake to diminish the perception of food reward while enhancing the response to satiety signals generated during food consumption.

Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/821eff5df3ccc2edcdd6027a93dd7f52f8b2e58a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. P. Kenny
2. U. Albrecht
3. Kent C. Berridge

In Nutrition and Dietetics

1. P. Kenny
2. U. Albrecht
3. Kent C. Berridge
4. Jaak Panksepp
5. S. Peciña
6. Morten L. Kringelbach
7. Jocelyn M. Richard
8. Chao-yi Ho

In Physiology

1. U. Albrecht
2. Kent C. Berridge
3. P. Kenny

Citations in the corpus

• Reward Mechanisms in Obesity: New Insights and Future Directions (2011, background): “Conversely, hyperphagic human patients with congenital leptin deficiency demonstrate increased activity in the insular cortex and striatum in response to images of food (Baicy et al., 2007; Farooqi et al., 2007).”
• The tempted brain eats: pleasure and desire circuits in obesity and eating disorders. (2010, neutral): “…implicating malfunction of leptin's ability to suppress 'wanting' or 'liking' in a particular form of genetic obesity: people born with a monogenic-based deficiency of leptin, who as children constantly demand food and soon become obese (Farooqi et al., 2007; Farooqi and O'Rahilly, 2009).”
• From prediction error to incentive salience: mesolimbic computation of reward motivation (2012, background): “In humans, a related (j, rt) interaction by physiological appetite ⁄ satiety state might apply to demonstrations by Farooqi and O’Rahilly and colleagues, who have studied brain activations elicited by food cues in leptin-deficient people (Farooqi et al., 2007; Farooqi & O’Rahilly, 2009).”
• Timing to perfection: the biology of central and peripheral circadian clocks. (2012, background): “Imaging studies in human subjects confirm the involvement of the mesolimbic dopamine (DA) system in leptin’s actions (Farooqi et al., 2007).”
• Pro v Con Reviews: Is Food Addictive? (2012, neutral): “Also in insular cortex (172), NAc (173),”