Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients.

By P. Brasnyó, G. Molnár, M. Mohás, L. Markó, B. Laczy, J. Cseh, E. Mikolás, I. Szijartó, Ákos Mérei, Richárd Halmai and 3 more. British Journal of Nutrition, 2011

661 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/8208127f973f4e96de12b6f9b5ac93b9b5e7f124

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

1. Joseph A. Baur
2. D. Sinclair
3. Brian J. North
4. L. Guarente

In Physiology

1. Joseph A. Baur
2. D. Sinclair
3. C. Palmeira
4. Brian J. North
5. Marina K. Holz
6. A. Rolo

Citations in the corpus

• Resveratrol and health--a comprehensive review of human clinical trials. (2011, methodology): “To date, there is only one peer-reviewed human clinical trial that addresses the effects of resveratrol on insulin sensitivity [57], and none on obesity.”
• Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review (2014, background): “models [177–185] and improves insulin sensitivity in type 2 diabetic patients [186], is also a ligand of PPARa [250,252], was co-crystallized with the PPARg-LBD”
• Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases (2012, positive): “Resveratrol also decreased insulin resistance in type 2 diabetic patients (Brasnyó et al., 2011), suggesting that the pathway targeted by resveratrol might be important for developing therapies for type 2 diabetes.”
• The therapeutic potential of resveratrol: a review of clinical trials (2017, background): “found that resveratrol activated the Akt insulin signaling pathway by increasing the phosphoAkt:Akt ratio in platelets.(64) Crandall et al.”
• SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function (2012, background): “Recent clinical studies show that resveratrol also confers metabolic benefits in humans (Brasnyo et al., 2011; Crandall et al., 2012).”