Distinct stem cells contribute to mammary gland development and maintenance

By A. Keymeulen, A. Rocha, M. Ousset, Benjamin Beck, Gaëlle Bouvencourt, J. Rock, N. Sharma, S. Dekoninck, C. Blanpain. Nature, 2011

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Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts (2013, background): “Under normal developmental conditions, each stem cell population gives rise to cells restricted to either the basal or luminal lineage (Van Keymeulen et al., 2011).”
Evolution of the cancer stem cell model. (2014, background): “Normal tissue stem cells can also ‘‘dedifferentiate’’ into a more primitive state when normal tissue homeostasis is perturbed, for example during transplantation procedures or following stem cell ablation (Rinkevich et al., 2011; Tata et al., 2013; Van Keymeulen et al., 2011).”
Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis (2018, background): “These mammary repopulating cells can be identified as adopting multipotent characteristics under regenerative conditions viewed through transplantation.(67,68) MaSCs are posited to exist in distinct microenvironment known as a stem cell niche, which places added importance on mutual feedback relatio”