Natural products as sources of new drugs over the period 1981-2002.

By D. Newman, G. Cragg, K. Snader. Journal of Natural Products, 2003

3,562 citations recorded by the source corpus.

Subfields: Oncology, Organic Chemistry, Pharmacology

View Paper: https://www.semanticscholar.org/paper/81d1d25b4b63c612306c6c22ae0a54b0e6da14e0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. D. Newman
2. G. Cragg
3. Bharat B. Aggarwal
4. A. Kinghorn
5. Marcy J. Balunas

In Organic Chemistry

1. M. Gordaliza
2. G. Cragg
3. D. Newman
4. W. Fenical
5. P. Jensen
6. C. Walsh
7. A. Kinghorn
8. C. D. Giovanni

In Pharmacology

1. M. Gordaliza
2. G. Cragg
3. D. Newman
4. Tilmann Weber
5. Bharat B. Aggarwal
6. A. Kunnumakkara
7. Kai Blin
8. K. Selim

Citations in the corpus

• Lessons from natural molecules (2004, background): “For example, between 1981 and 2002, 5p of the 1,031 new chemical entities approved as drugs by the US Food and Drug Administration (FDA) were natural products, and another 23p were natural-product-derived molecule”
• Plants as a source of anti-cancer agents. (2005, background): “Nevertheless, despite these observations, plants ave played an important role as a source of effective anticancer agents, and it is significant that over 60% of currently used anti-cancer agents are derived in one way or another from natural sources, including plants, marine organisms and micro-orga”
• Sustainability and cyanobacteria (blue-green algae): facts and challenges (2011, background): “Cyanobacteria produce a number of bioactive compounds of potential therapeutic use (Skulberg 2000; Newman et al. 2003; Newman and Cragg 2004a, b; Tan 2007; Gademan and Portman 2008; Jones et al. 2009; Tan 2010).”
• Natural products as leads to anticancer drugs (2007, background): “), apart from other new natural compounds that in the future may be developed into new drugs or leads, which –through further modifications– could afford more potent, more selective and less toxic compounds than currently available anti-cancer drugs [1, 20] (Fig.”
• Drug discovery from medicinal plants. (2005, background): “…chemistry, and other synthetic chemistry techniques by pharmaceutical companies and funding organizations, natural products, and particularly medicinal plants, remain an important source of new drugs, new drug leads, and new chemical entities (NCEs) (Newman et al., 2000, 2003; Butler, 2004).”