A nuclear export signal in the N-terminal regulatory domain of IκBα controls cytoplasmic localization of inactive NF-κB/IκBα complexes

By Tony T. Huang, N. Kudo, Minoru Yoshida, S. Miyamoto. 2000

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Molecular Basis of NF-κB Signaling (2013, background): “NF-κB proteins bind as a homo- or heterodimer to a 10-base-pairDNAsequence first identified in the enhancer of the immunoglobulin κ-light-chain gene in mature B cells (27, 38, 41, 43, 46, 102, 107).”
Persistently-activated Stat3 maintains constitutive NF-κB activity in tumors (2009, positive): “Cancer Cell 15, 283–293, April 7, 2009 ª2009 Elsevier Inc. 283 It has been suggested that NF-kB/IkBa can shuttle in and out of the nucleus in the absence of stimuli, although the rate of nuclear export is greater than the rate of nuclear import (Huang et al., 2000).”
The NF-κB pathway (2005, background): “Importantly, a nuclear export signal (NES) in I Bprecludes high steady-state levels of these complexes in the nucleus (Huang et al., 2000).”