Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome

By C. Hofstetter, N. Holmström, J. Lilja, P. Schweinhardt, Jinxia Hao, C. Spenger, Z. Wiesenfeld‐Hallin, S. Kurpad, J. Frisén, L. Olson. Nature Neuroscience, 2005

658 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/81cd75a4cce5f1099db835331c2f9665b00dadae

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. J. Gensel
2. Z. Kokaia
3. O. Lindvall
4. J. Frisén
5. David J. Loane
6. Alok Kumar

In Developmental Neuroscience

1. Z. Kokaia
2. O. Lindvall
3. J. Frisén
4. Hongjun Song
5. Guo-li Ming
6. Fred H. Gage

In Pathology and Forensic Medicine

1. J. Gensel
2. David J. Loane
3. Alok Kumar

Citations in the corpus

• Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord (2009, background): “This type of growth is reminiscent of the afferent sprouting that occurs at sites of spinal cord injury and is believed to cause neuropathic pain, spasticity, and autonomic dysreflexia (Weaver et al., 2001; Hofstetter et al., 2005; Hou et al.,”
• Stem cells for the treatment of neurological disorders (2006, background): “Astrocytic differentiation and aberrant axonal sprouting after NS-cell implantation into injured rat spinal cord can cause hypersensitivity to stimuli that are not normally painfu”
• Origin of new glial cells in intact and injured adult spinal cord. (2010, background): “Improved functional recovery after transplantationof in vitro expandedneural stemcells derived from theadult spinal cord (Hofstetter et al., 2005) demonstrates that there are stem cells in the adult spinal cord that can exert beneficial effects after injury, but fail to do so efficiently under norma”