Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content.

By B. Goodpaster, D. Kelley, F. Thaete, Jing He, R. Ross. Journal of applied physiology, 2000

903 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/81ac48a88c5c2c96dc859d440a0fea4a1370461b

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Citations in the corpus

Sarcopenia: revised European consensus on definition and diagnosis (2018, background): “resonance Spectroscopy (MRS) Goodpaster (2000) [53]”
Longitudinal study of muscle strength, quality, and adipose tissue infiltration. (2009, background): “We reported previously that lower attenuation values of muscle on computed tomography (CT), a marker of greater muscle fat content (5) are associated with lower muscle strength and muscle quality (MQ) (ie, lower strength per muscle size) (6).”
Dynapenia and aging: an update. (2012, background): “The causes of this reduction are yet to determined, but several studies have noted age-related changes in the excitation–contraction coupling processes (105– 108) and an association with adipocyte infiltration (109,110).”
Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study. (2001, background): “Because mean muscle attenuation values are a direct measure of reduced muscle density (5) and are associated with an increased lipid accumulation within muscle (8), our results indicate that skeletal muscle lipid content was higher with increasing age and overall adiposity and was higher in women.”
Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. (2005, methodology): “Lower attenuation values are compatible with greater fatty infiltration into tissue.(15) Intermuscular AT was distinguished from the subcutaneous AT by manually drawing a line along the deep fascial plane surrounding the thigh muscles, ensuring that no bone density pixels were included in the muscle”
Sarcopenia: etiology, clinical consequences, intervention, and assessment (2009, background): “The CSA values of the total thigh muscle and quadriceps muscle are positively associated with increasing knee extensor strength [118].”
Measurement of skeletal muscle radiation attenuation and basis of its biological variation (2014, background): “Some authors defined low attenuation muscle from 0 to +29 HU (Goodpaster et al. 2000b, Deriaz et al. 2001, Lee et al. 2005), while others included 29 to +30 HU.”
Age-related changes in total and regional fat distribution. (2009, neutral): “…fat depot is also difficult to assess, primarily because measurement methods are restricted to muscle biopsy or radiological techniques such as CT or MRS (Wendling et al., 1996; Boesch et al., 1999; Szczepaniak et al., 1999; Boesch and Kreis, 2000; Goodpaster et al., 2000b; Schick et al., 2002).”
The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. (2006, methodology): “Muscle attenuation values were also measured as a marker of muscle composition (23).”