TGF-β signaling in renal disease

By Erwin P. Bottinger, M. Bitzer. 2002

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TGF-β/Smad signaling in renal fibrosis (2015, background): “Considerable evidence revealed that TGF-β is substantially upregulated in the injured kidney on both patients and animal disease models (Yamamoto et al., 1996; Bottinger and Bitzer, 2002).”
Methylation determines fibroblast activation and fibrogenesis in the kidney (2010, neutral): “Two distinct mechanisms of transcriptional silencing To gain additional insights into Rasal1 expression and Rasal1 methylation, we exposed primary mouse kidney fibroblasts to transforming growth factor-β1 (TGF-β1), which is known to induce fibroblast activation in vitro”
TGF-β and epithelial-to-mesenchymal transitions (2005, background): “…body of work established new roles for TGF-bs as important mediators of tumor progression, and in progression of chronic fibrotic disorders, in particular chronic kidney disease (reviewed in Border and Noble, 1994; Derynck et al., 2001; Bottinger and Bitzer, 2002; Roberts and Wakefield, 2003).”