Untranslated regions of mRNAs

By F. Mignone, Carmela Gissi, S. Liuni, Graziano Pesole. Genome Biology, 2002

1,007 citations recorded by the source corpus.

Gene expression is finely regulated at the post-transcriptional level. Features of the untranslated regions of mRNAs that control their translation, degradation and localization include stem-loop structures, upstream initiation codons and open reading frames, internal ribosome entry sites and various cis-acting elements that are bound by RNA-binding proteins.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/818ff0d4d8229358a5042096fa6e50632f8aac4e

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Citations in the corpus

UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs (2009, background): “Such regulation is mostly mediated by cis-acting elements located in the 50 and 30 untranslated regions of mRNAs (50UTR and 30UTR) (1) and miRNAs interacting with their specific targets in 30UTRs (2,3).”
OrfPredictor: predicting protein-coding regions in EST-derived sequences (2005, background): “start codons is further complicated because there is not a universal consensus sequence surrounding eukaryotic start codons, although the conserved consensus sequence, GCCRCCaugG (R: purine; aug: start codon) is present in mammals (4).”
Regulating gene expression through RNA nuclear retention. (2005, methodology): “In order to characterize the population of poly(A)+ RNA enriched in nuclear IGCs and associated nuclear domains, we biochemically purified the IGC fraction from mouse liver nuclei (Mintz et al., 1999; Saitoh et al., 2004), isolated poly(A)+ RNA, and constructed a plasmid-based cDNA library.”
Current methods of gene prediction, their strengths and weaknesses. (2002, background): “They are known to play a role in the post-transcriptional regulation of gene expression, such as the regulation of translation and the control of mRNA decay (18).”
microRNA Target Predictions across Seven Drosophila Species and Comparison to Mammalian Targets (2005, result): “We found a much broader distribution of 3 9 UTR lengths in mammals than in ﬂies, yielding on average approximately 900 nucleotides per 3 9 UTR for human and approximately 400 nucleotides per 3 9 UTR in D. melanogaster (Figure 6), consistent with previous results [28].”
All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPs (2013, background): “The 59UTR, specifically, is important for the regulation of gene expression [33] making it a compelling candidate for playing a causal role in complex trait variation [1].”
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. (2005, background): “It is likely that many conserved 3 -UTR sequences are involved in posttranscriptional regulatory mechanisms, e.g., by influencing subcellular localization, transcript stability, or translatability (Duret et al. 1993; Grzybowska et al. 2001; Mignone et al. 2002).”
Extensive Association of Functionally and Cytotopically Related mRNAs with Puf Family RNA-Binding Proteins in Yeast (2004, methodology): “Average lengths of predicted UTR sequences (134 bp of 59-UTR sequences, 237 bp of 39-UTR sequences; Mignone et al. 2002).”
A hitchhiker's guide to expressed sequence tag (EST) analysis (2006, background): “ESTs and untranslated regions (UTRs) The 50 and 30 UTRs of eukaryotic mRNA have been experimentally shown to contain sequence elements essential for gene regulation, expression and translation [16].”