Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment

By K. Hattori, B. Heissig, Yan Wu, S. Dias, Rafael E. Tejada, B. Ferris, D. Hicklin, Zhen-ping Zhu, P. Bőhlen, L. Witte and 7 more. Nature Medicine, 2002

684 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/816ceec02d218f2b11e0ee5c99e79044306de68a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Peter Carmeliet
2. Stuart H. Orkin
3. Zena Werb
4. D. Lyden
5. D. Hanahan
6. P. Patterson

In Molecular Biology

1. N. Ferrara
2. D. Hanahan
3. Peter Carmeliet
4. J. Joyce
5. Rakesh K. Jain
6. Zena Werb
7. Stefanie Dimmeler
8. D. Hicklin

Citations in the corpus

• Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? (2002, background): “, and by a subpopulation of haematopoietic stem cell”
• Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. (2004, background): “…mice (Lyden et al., 1999) or placental growth factor null mice The host contribution to tumor progression is reflected by (Carmeliet et al., 2001; Hattori et al., 2002) restored their ability the roles of tumor infiltrating cells, which orchestrate the tumor to form tumor blood vessels and…”
• Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration (2003, background): “However, the angiogenic switch promotes mobilization of bone marrow–derived EPC”
• Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer (2004, background): “However, growing evidence supports the idea that VEGFR1 has important roles in haematopoiesi”
• The biology of VEGF and its receptors (2003, background): “VEGFR-1 activation by PLGF is able to reconstitute hematopoiesis by recruiting VEGFR-1-positive HSC”
• VEGF receptor signalling ? in control of vascular function (2006, background): “The important role of VEGFR1 in haematopoietic-cell function is furthermore underscored by the fact that PLGF-stimulated VEGFR1-positive HPCs can rescue haematopoiesis after bone-marrow destructio”
• Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. (2007, methodology): “Similar data were obtained when correcting the data for protein content.”
• Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells (2003, background): “MMP-9, which is essential for VEGF- and 5-FU-induced stem cell mobilizatio”