Secreted microRNAs: a new form of intercellular communication.

By X. Chen, Hongwei Liang, Junfeng Zhang, Ke Zen, Chen-Yu Zhang. Trends in Cell Biology, 2012

751 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/816b18f294cb88edfd0b5337444f730d9cbd4bb6

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Citations in the corpus

Non-coding RNAs in disease: from mechanisms to therapeutics (2023, positive): “…mRNA causing its post-transcriptional inhibition, whereas miR-10a binds to the 5′ UTR of ribosomal-encoding mRNAs, such as Rps16 , and enhances their translation. c , miRNAs can act as mediators of intracellular communication by being secreted via extracellular vesicles and acting as hormones 41 .”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “In contrast to this active secretion of ncRNAs, there is also a number of miRNAs entering the circulation system through passive leakage (45).”
Structure and dynamics of molecular networks: A novel paradigm of drug discovery: A comprehensive review (2012, methodology): “Analysis of pathogen interactomes involving random walks or known drug resistance-related proteins plus gene expression changes revealed pathways often involved in resistance development helping cotarget determination (Raman & Chandra, 2008; Chen et al., 2012b).”
Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery* (2014, background): “Neighboring and distant tumor cells can receive information from tumor exosomes (9, 16).”
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018, background): “It has been proposed that vesicleassociated extracellular miRNAs may enter cells by endocytosis, phagocytosis, or direct fusion with the plasma membranes, while vesicle-free secreted miRNAs may be taken up by specific receptors on the cell surface (140).”
Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “Their involvement in various types of cancer-related processes, such as angiogenesis and metastasis, suggests that they can be considered as non-invasive biomarkers for cancer diagnosis [55,208].”